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Green Tea Polyphenols and Metabolites in Prostatectomy Tissue: Implications for Cancer Prevention.
Cancer Prev Res 2010 Jul 13.
Wang P, et al
Abstract
Epidemiologic, preclinical, and clinical trials suggest that green tea consumption may prevent prostate cancer through the action of green tea polyphenols including (-)-epigallocatechin-3-gallate (EGCG).
To study the metabolism and bioactivity of green tea polyphenols in human prostate tissue, men with clinically localized prostate cancer consumed six cups of green tea (n = 8) daily or water (n = 9) for 3 to 6 weeks before undergoing radical prostatectomy.
Using high-performance liquid chromatography, 4''-O-methyl EGCG (4''-MeEGCG) and EGCG were identified in comparable amounts, and (-)-epicatechin-3-gallate was identified in lower amounts in prostatectomy tissue from men consuming green tea (38.9 +/- 19.5, 42.1 +/- 32.4, and 17.8 +/- 10.1 pmol/g tissue, respectively).
The majority of EGCG and other green tea polyphenols were not conjugated. Green tea polyphenols were not detected in prostate tissue or urine from men consuming water preoperatively.
In the urine of men consuming green tea, 50% to 60% of both (-)-epigallocatechin and (-)-epicatechin were present in methylated form with 4'-O-MeEGC being the major methylated form of (-)-epigallocatechin. When incubated with EGCG, LNCaP prostate cancer cells were able to methylate EGCG to 4''-MeEGCG.
The capacity of 4''-MeEGCG to inhibit proliferation and NF-kappaB activation and induce apoptosis in LNCaP cells was decreased significantly compared with EGCG.
In summary, methylated and nonmethylated forms of EGCG are detectable in prostate tissue following a short-term green tea intervention, and the methylation status of EGCG may potentially modulate its preventive effect on prostate cancer, possibly based on genetic polymorphisms of catechol O-methyltransferase.
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In the Media on Tea!
Kombucha is steeped in controversy
The fermented tea drink looks like 'probiotic' health food to some, moldy risk to others
By Laura Vozzella
The Baltimore Sun
June 23, 2010
Herbal teas, including all the teas discussed in these pages, should not be consumed by persons who are pregnant or nursing, unless approved by your health care provider. Herbal teas may vary in their ingredients and some herbal tea components may interfere with other important medications. For example, there is some concern that green tea ingestion during pregnancy may reduce the absorption of folate, an important nutrient in fetal nervous system development.
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Masala Indian Spiced Tea, Moroccan Tea, Mint Tea, Lemongrass Tea, Yerba Tea, Kombucha Tea
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