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Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule
67-kDa laminin receptor.
PLoS One. 2010 Jun 10;5(6):e11051.
Lee JH et al
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki, Japan.
Abstract
BACKGROUND: Green tea consumption has been shown to have cancer preventive qualities. Among the constituents of green tea, (-)-Epigallocatechin-3-O-gallate (EGCG) is the most effective at inhibiting carcinogenesis. However, the concentrations of EGCG that are required to elicit the anticancer effects in a variety of cancer cell types are much higher than the peak plasma concentration that occurs after drinking an equivalent of 2-3 cups of green tea. To obtain the anticancer effects of EGCG when consumed at a reasonable concentration in daily life, we investigated the combination effect of EGCG and food ingredient that may enhance the anticancer activity of EGCG on subcutaneous tumor growth in C57BL/6N mice challenged with B16 melanoma cells.
METHODOLOGY/PRINCIPAL FINDINGS: All-trans-retinoic acid (ATRA) enhanced the expression of the 67-kDa laminin receptor (67LR) and increased EGCG-induced cell growth inhibition in B16 melanoma cells. The cell growth inhibition seen with the combined EGCG and ATRA treatment was abolished by treatment with an anti-67LR antibody. In addition, the combined EGCG and ATRA treatment significantly suppressed the melanoma tumor growth in mice. Expression of 67LR in the tumor increased upon oral administration of ATRA or a combined treatment of EGCG and ATRA treatment. Furthermore, RNAi-mediated silencing of the retinoic acid receptor (RAR) alpha attenuated the ATRA-induced enhancement of 67LR expression in the melanoma cells. An RAR agonist enhanced the expression levels of 67LR and increased EGCG-induced cell growth inhibition.
CONCLUSIONS/SIGNIFICANCE: Our findings provide a molecular basis for the combination effect seen with dietary components, and indicate that ATRA may be a beneficial food component for cancer prevention when combined with EGCG
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In the Media on Tea!
Kombucha is steeped in controversy
The fermented tea drink looks like 'probiotic' health food to some, moldy risk to others
By Laura Vozzella
The Baltimore Sun
June 23, 2010
Herbal teas, including all the teas discussed in these pages, should not be consumed by persons who are pregnant or nursing, unless approved by your health care provider. Herbal teas may vary in their ingredients and some herbal tea components may interfere with other important medications. For example, there is some concern that green tea ingestion during pregnancy may reduce the absorption of folate, an important nutrient in fetal nervous system development.
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Masala Indian Spiced Tea, Moroccan Tea, Mint Tea, Lemongrass Tea, Yerba Tea, Kombucha Tea
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